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Premarin Cancer & Heart Disease Lawsuit

Premarin is the brand name for a combination estrogen hormonal replacement drug. Prescribed to treat symptoms that go along with menopause, as well as to treat breast cancer and prostate cancer, Premarin has been shown to cause heart disease and several types of cancer in some patients.

If you believe you’ve suffered harm as a result of taking Premarin, contact RLG for a free consultation . We might be the Premarin law firm you are looking for. To file a lawsuit for injuries you suffered as the result of a medicine you took, that medicine doesn’t have to have been recalled.

You shouldn’t have to go through a lot of hassle to receive compensation for the injuries you’ve suffered. The Rottenstein Law Group knows this, and we want you to believe it. You need a sympathetic advocate who will represent only your interests—and who will make the process of obtaining compensation for your injuries as painless as possible.

What Is Premarin and What Is It Prescribed For?

Made and sold by Wyeth Pharmaceuticals, which Pfizer purchased in 2009, this prescription medication is used to treat several symptoms brought on by menopause, specifically:

(1)  Severe vasometer symptoms (hot flashes);
(2)  Vulvar and vaginal atrophy;
(3)  Hypoestrogenism (estrogen deficiency); and
(4)  Osteoporosis.

Doctors also prescribe Premarin as a breast cancer or prostate cancer treatment.

The U.S. Food and Drug Administration (FDA) approved Premarin in oral tablet form in 1942, as an intravenous solution in 1956, a topical cream in 1978, and again in tablet form at lower doses for osteoporosis treatment. Premarin is a common drug, with as many as six million people using it worldwide.

Premarin combines three forms of estrogen derived from sodium salts of hormones found in horse urine: sodium estrone sulfate (50%), sodium equilin sulfate (15-25%), and sodium equilenin sulfate (25-35%). The sodium estrone sulfate is the most active component of the combination, and the human body can easily convert it into estradiol. Once metabolized, the estradiol replaces the patient’s diminished hormones, thereby alleviating her menopause symptoms.

Premarin Side Effects Include Cancer and Heart Disease

Studies have shown that Premarin causes three types of cancer, endometrial cancer (cancer of the membrane of the uterus), breast cancer, and lung cancer. According to the Premarin drug label, users can develop endometrial cancer at a rate of two to 12 times greater than non-users. The longer a woman stays on Premarin, the more the likelihood of her developing cancer increases. Women who use the drug for less than one year do not show much of an increased risk, but those who take it for five to ten years are 15 to 25 times more likely to develop endometrial cancer. The risk persists eight to 15 years after use.

When Premarin is used with the hormone progestin (medroxyprogesterone acetate), such as in the combined drug Prempro, users are more likely to develop breast cancer than non-users. According to the Women’s Health Initiative (WHI) substudy of women who took 0.625 mg of Premarin combined with 2.5 mg of progestin, those who took Prempro in the past were 1.86 times more likely to develop breast cancer than those who took the placebo. The cancers in women who took the hormones were larger and more advanced than in those who did not take them. Although women who used Premarin alone did not show increased risk of cancer, the FDA states that it has received reports that Premarin users produce abnormal mammograms, leading the FDA to recommend that these women receive yearly breast examinations and perform their own breast examinations monthly.

A September 2009 study published in The Lancet established that women who used Premarin with progestin were 71 percent more likely to die from lung cancer than those who took a placebo. For hormone replacement drug users, the likelihood of developing lung cancer increased 28 percent, though the researchers cautioned that the increased risk was not statistically significant.

The WHI substudy also found that Premarin, whether used alone or with progestin, can cause several cardiac side effects, including:

  • Stroke;
  • Deep vein thrombosis;
  • Venous thromboembolism; and
  • Myocardial infarction.

The FDA recommends discontinuation of estrogen replacement therapy if any of these events occurs.

Breast Cancer Victims Are Suing Premarin’s Manufacturer

Because of the breast cancer risk associated with Premarin when combined with progestin, plaintiffs in the U.S. and now Canada have filed Premarin breast cancer lawsuits against Wyeth and its parent, Pfizer. In the U.S. 10,000 women filed lawsuits, and in May 2011, Pfizer agreed to settle those suits for $772 million. In Canada, on August 5, 2011, the Supreme Court of British Columbia certified a class action Premarin lawsuit against Pfizer and Wyeth.

In July 2012, a Pennsylvania appellate court upheld a Premarin plaintiff’s jury award of $10.4 million in damages because it was not excessive, according to Bloomberg. Audrey Singleton sued Wyeth over Premarin injuries, and in 2010 a jury awarded her $3.4 million in compensatory and $6 million in punitive damages, and the trial court added $1 million in interest.

RLG’s Lawyers Will Make Things Easier

The process of demanding compensation for the harm you’ve suffered can be complicated, even if it doesn’t seem fair that you should have to go through even more trouble to be made whole again. The lawyers at the Rottenstein Law Group believe that getting satisfaction from the company that manufactured a drug that you believe harmed you shouldn’t be just more hardship. That’s why we do everything we can to streamline the process, and we will file a Premarin lawsuit on your behalf if necessary. RLG will also keep you up to date on any Premarin class action lawsuits, FDA Premarin warnings, and Premarin FDA recall announcements.

If you have taken Premarin and experienced adverse side effects, contact RLG today.

Join the Discussion

Please note: Comments are encouraged in order to permit visitors to discuss relevant topics. Comments are moderated and might be edited by RLG before being published.

Comments should not be used to ask questions of RLG’s lawyers; if you want to speak with a lawyer, please fill out this contact form or call 1 (888) 976-8529. *Your name and email address will not be published.

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rlg Previous Comments

  1. Guest
    on November 21, 2012 at 6:38 pm

    I took Premarin since the 80's and got endometrial cancer (Stage 2); I had to have a complete hysterectomy. I am still taking it; and I have tried to go off it now for (7) times. I am really scared; but I can't function if I don't have it in my system. My main concern now; however is that my sister is presently dying of pancreatic and liver cancer, (Stage 4). We have a first cousin who also had it, and died in her early 60's. My sister just turned 70 and I am 67.

  2. Guest
    on November 19, 2012 at 8:44 pm

    A good friend of mine died from ovarian cancer after more than 22 years of premarin use.

  3. Guest
    on October 24, 2012 at 8:34 am

    Premarin made me loose both breasts last year at age 35.

  4. Guest
    on August 14, 2012 at 5:57 pm

    My wife took Premarin from 1995 until about 2002. She has recently been diagnosed with breast cancer which, according to pathology, has been growing for around 10 years. It just showed up on her mammogram in June of this year.

  5. Guest
    on August 2, 2012 at 3:21 pm

    I had a mastectomy 24 years ago and it was progestrian and estrogen positive. I had been taking Premarin, unfortunately I do not remember after all these years, how long I took it. My doctor did not give me radiation and now the same cancer has come back and is in my skull and lining of my brain. I am now stage 4 brain cancer.

  6. Guest
    on July 27, 2012 at 3:25 am

    I had a stroke in 2002 nine months after being placed on the drug after I had a hysterectomy.

  7. Guest
    on May 2, 2012 at 12:57 pm

    I took Premarin and do have cancer. (breast cancer, female cancer, thyroid cancer)

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