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Lyrica Angioedema & Suicidal Side Effects

Research shows the anticonvulsant drug pregabalin—sold under the brand name Lyrica—causes suicidal ideation and behavior and angioedema. The Rottenstein Law Group compassionately advocates for those who have suffered from the harmful side effects of potentially dangerous drugs. If you’ve taken Lyrica and believe it harmed you, contact RLG for a free, confidential legal consultation immediately. We will evaluate your case and remain on the lookout for Lyrica recalls and Lyrica class action lawsuits. We might be the Lyrica law firm you are looking for.

What Is Lyrica and What Is Prescribed For?

Lyrica is the brand name for the drug pregabalin. Made and sold by U.S. pharmaceutical giant Pfizer, this prescription medication is used to treat neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, partial onset seizures. It is also the first drug approved for treating fibromyalgia.

The U.S. Food and Drug Administration (FDA) approved Lyrica in December 2004, and Pfizer sells it in 25 mg to 300 mg oral capsules. Lyrica is Pfizer’s third highest-selling drug by revenue; Pfizer earned more than $3 billion in Lyrica sales. Pfizer’s Lyrica patent will expire in 2013.

Pfizer designed Lyrica to be the successor to the neuropathic pain reliever gabapentin. According to Lyrica’s label, “[T]he mechanism of action of pregabalin has not been fully elucidated.” Scientists believe Lyrica reduces the release of neurotransmitters that mediate pain signals from the brain.

According to the BBC, Pfizer settled the largest ever fraud claim against the U.S. Department of Justice (DOJ) for $2.3 billion. Whistleblowers informed the DOJ that Pfizer was marketing various drugs, including Lyrica, for off-label uses. The DOJ and state attorneys general took on their cases under the False Claims Act. Pfizer signed a “corporate integrity agreement” with the United States government.

Lyrica Suicidal Ideation and Behavioral Side Effects

Although Lyrica’s packaging does not carry any of the FDA’s most serious warnings (i.e., “black box” warnings), it does cause some serious side effects.

In late 2008, the FDA required antiepileptic manufacturers to include warnings on their drug labels stating that the drugs cause suicidal thoughts and behaviors in users. This requirement is based on a study of 199 placebo-controlled clinical trials that showed that antiepileptic users experienced suicidal thoughts at double the rate of the placebo population (0.43% vs. 0.24%).

An unknown number of people reported to the FDA that they experienced angioedema while taking Lyrica. Angioedema is the term for swelling of the face, mouth, or neck. Neck swelling can be life-threatening.

The most common general side effects, according to Lyrica’s label are:

  • Dizziness;
  • Blurred vision;
  • Weight gain;
  • Sleepiness;
  • Skin hypersensitivity;
  • Difficulty concentrating;
  • Edema (swelling of the hands or feet);
  • Dry mouth;
  • Soreness and muscle pain; and
  • Feeling “high.”

RLG’s Lawyers Will Make Things Easier

The process of demanding compensation for the harm you’ve suffered can be complicated, even if it doesn’t seem fair that you should have to go through even more trouble to be made whole again. The lawyers at the Rottenstein Law Group believe that obtaining legal satisfaction from those who harmed you shouldn’t require more hardship. That’s why we do everything we can to streamline the process, and we will file a Lyrica lawsuit on your behalf if necessary. RLG will also keep you up to date on any Lyrica class action lawsuits, FDA Lyrica warnings, and Lyrica FDA recall announcements.

If you have taken Lyrica and believe it harmed you, contact RLG today.

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Please note: Comments are encouraged in order to permit visitors to discuss relevant topics. Comments are moderated and might be edited by RLG before being published.

Comments should not be used to ask questions of RLG’s lawyers; if you want to speak with a lawyer, please fill out this contact form or call 1 (888) 976-8529. *Your name and email address will not be published.



rlg Previous Comments

  1. Guest
    on November 30, 2012 at 3:07 pm

    I suffered long term memory loss after taking Lyrica.

  2. Guest
    on September 18, 2012 at 9:09 am

    Hi all, I am sorry for you all and your suffering, I am finally glad that a law firm can get this drug off the market before it ruins many others lives. In 2005, I had a severe spinal cord injury and developed nerve damage from it. I was put on Lyrica and little did I know that it was doing more damage than good. I was increased to 900 mg a day and was on that dosage for awhile. I was so very injured among other tragedies. I wasn't paying attention to my confusion and my extreme memory loss was long and short term. I had my teeth start to deteriorate and almost all rotted right out of my head. I got to the point of seriously ending my life, I thought about it daily and once was about to do it and my fiance caught me and started locking up my meds. I could have never dreamed I was so bad but Lyrica has destroyed my life. I can tell you that it also it was not an easy drug to come off of. I am now down to 150 mg and plan some time next month to drop again. You can not just stop taking it. It could be life threatening. I have a hard time talking or getting my words out. Something like this note can take me over an hour to write. I cant even order a pizza because I cant talk or remember in the middle of ordering. I was a professional for 35 years, now I cant even speak. It is very embarrassing. I am hopeful that this law firm or some other law firm will see how bad this drug is and others who haven't been put on it yet, not be. I believe many of us from the beginning, years ago must have been their guinea pigs. I don't believe it is fair. So please know you are not alone. I will pray that someone will finally listen because I tried for years to get someone to listen, I just gave up and when I noticed last night that one of Lyrica survivor's group had this firms website up I was excited. Please help us, there are many out there, I would hate to think that it takes a death before action will be taken, heck we don't really know if it already hasn't happened yet! God Bless you all, and I will pray for you all!

  3. Guest
    on September 17, 2012 at 8:46 pm

    Thank you so much for coming forward to defend those of us that Lyrica has harmed. I have been taking 300mg capsules 4 times a day for the last 4 years. The side effects are unbearable, and yes I have contemplated suicide many times. Actually loaded my gun numerous times. I felt like I wasn't good enough for my family. I have tried many times to stop taking lyrica, but the effects from that are even worse. I cannot eat, drink, or sleep when I try to stop it. That went on for 2 weeks one time and I was so weak I could not move. I asked my doctor to help me several times, and he did nothing until 2 weeks ago. He lowered my dosage to 150mg 4 times daily. I guess he heard about the lawsuit. I have had major swelling of my feet and ankles and neck causing shortness of breath. I never told anyone because I was so tired of the control it had over my life, I was, and still am ready to just die. I have uncontrollable muscle jerking, so I stopped driving. I have lost over 50% of the muscle mass in my arms and legs, and uncontrollable shaking all of the time, but I have gained a lot of weight, and now have been diagnosed as diabetic. I have very bad mental confusion, can't remember my wife and daughters name at times. And anything that requires serious thought, I have to depend on my wife to help me through it. I have been such a burden on my family, and the hurt on my little girls face when I can't remember her name makes her cry. I can't even figure out why she is crying until I have a "good" day, and then my wife explains it to me. I feel totally worthless, and in my present state, I am worthless. I was diagnosed as having a inoperative back injury in 2004 due to a on the job accident. My doctor prescribed lyrica to help with the pain, and it did, but in time the pain from the drug (physical and mental) has been much worse than my original injury. I was a pilot and jet mechanic for high performance jets, and worked at NASA before for almost 10 years, so I was no clown. NASA doesn't let just anyone in the door, and I had to have a major background check done by the FBI for security clearances which I passed with flying colors. All my little girl wants is her daddy back. Can you please help me, I want treatment and compensation for all of the horror this has caused to myself and family. I want to be off of this drug, it is like a very long slow-death. I have asked many doctors to help me, but they keep referring me back to the prescribing doctor, and he really has done nothing to help. I truly hope you can help. Thank you for your time.

  4. Guest
    on September 17, 2012 at 5:47 pm

    I was on Lyrica for many years, I was on neurontin before that. My pain specialist suggested Lyrica, I remember doing the research on Lyrica, all the ill feelings, suicidal thoughts, rage, I literally walked around every day saying "I hate my life I wish I was dead". My anxiety was through the roof, there were days I would get in my car driving down the road screaming as loud as I could. I took myself off this horrible drug last year, I was on 600 mg and I came off very fast, I cried for two weeks, I was sick, nauseous, hot and cold. I felt like I was going to die. Looking back, six months ago my thought process is better but not 100%. How many people that will have to go through what I went through and what many others have gone through because this horrible drug is still on the market.

  5. Guest
    on September 17, 2012 at 4:08 pm

    I was on Lyrica for over a year, and it ruined my life. All the symptoms above and a few more, that even after ending the drug persist. I used to complain to my doctor part of my brain was quieted and did not work. I have been unable to work, drive nor process incoming stimulus and information as well as before. Thank god for the computer and assistance it give because if I had to write this it would be unreadable. Please if someone went to jail for fraud concerning this drug isn't it time to put a hold on it sale and look at clinical trials again? I don't even know if my doctor reported this to the FDA, as he kept telling me the symptoms were not from the drug! They also claim it is not addictive and that is a Bald Face Lie - It is highly addictive! I have begged my children if I do not recover to please pursue in my name. It's getting very difficult to keep going.

  6. Guest
    on September 15, 2012 at 12:55 pm

    I am from Ireland & 4 years ago I had 4 siblings who died within a 24 month period. My brother Aidan died by suicide. He and I looked after our older brother Patrick for 25 years. He was the victim of a hit and run and received serious head injury. He was hospitalized in a Mental Hospital for the rest of his life. I dealt with death with drink and Waylon Jennings country music, whereas my brother had no way to deal with his sorrow. He died, I collapsed and was admitted to hospital with kidney damage, diabetes and a week later with Diabetic neuropathy.

    I was prescribed Insulin 30mg twice a day by injection and I was prescribed LYRICA for my neuropathy. I accepted pain as if it was the price I had to pay for my condition and NEVER questioned my medication, UNTIL this week. I had being getting severe cramps all over my body and Tinnitus in my ear. I decided to check out LYRICA and its side effects and was blown away with what I found. The Sh-t hit the proverbial fan! Everything fell into place. The depression, the anger, the pain I had been suffering for months, NOW had a REAL cause - LYRICA. I will do Cold Turkey on this dangerous drug, no matter what doctors say! I want to get better!

  7. Guest
    on September 1, 2012 at 4:47 pm

    I have had the side effect of dry mouth. I was told by a dentist that all my teeth needs to be pulled and my inside jaw bone has to be cut out for dentures. Then I was told that I will have trouble with dentures fitting because of the dry mouth. I can not afford all this, and my teeth hurt everyday.

  8. Guest
    on August 30, 2012 at 11:06 am

    My problem symptoms are entirely different than any of these mentioned. My side effects have been joint movements, like dislocation. I never had this problem before, it was worse while I was taking it, and I still have the problems with my knees. After reading the forum and all the different side affects, I realize I have had some of those as well, just not to the degree as others.

  9. Guest
    on August 29, 2012 at 8:19 pm

    I live in Australia, my wife was on pregabalin in 2008 for rheumatoid arthritis. After a couple of months she started to become so withdrawn and non communicative she barely left the bedroom for 6 weeks. She then emerged one day a completely different person, as if she was totally off her face. She slurred her words, talked gibberish, stumbled around without any balance, would fall asleep mid-sentence standing up! Our daughter was six months old at the time, I had to leave my job to care for her. My wife went on spending sprees and blew all our savings. On occasions I found her in the middle of the night asleep on all fours on the kitchen floor with food upturned and her medications scattered everywhere. I was scared she would overdose and die but no matter how hard I tried to communicate with her I couldn't get through. Any attempts to stop her behavior resulted in explosions of rage so severe I feared for my safety. It peaked around Christmas so of course all her doctors were on holiday. It was a heartbreaking living nightmare. Fortunately just when I had given up all hope, she got a dose of flu/gastro so bad she was unable to take pregabalin for about a week and suddenly she came back to reality, mostly. She has no memory of that time, about 4 to 5 months, including our daughters first Christmas. For the next 6 months she was still so impaired that she would endlessly repeat the same conversation. Worst of all that close connection we had always had was gone, simply vanished. It was impossible to communicate with her and my family was no help as they all thought she had gone nuts and wanted nothing to do with her. After another 18 months caring for her, looking after my daughter full time, doing all the housework, working part time from home and at night when I could I couldn't bear it anymore and we separated. Two years later she is about 80-85% better but still struggles. This drug has cost me so much, my wife, my finances, my family. I've read that Pfizer has been fined in the US for falsifying its research results regarding this drug, yet here in Australia there is a big push to treat all chronic pain sufferers with pregabalin and my wife is constantly being told by doctors to go back on it and has been ridiculed when she tells them what happened. It is criminal, corrupt, callous and cruel and I hope the people responsible suffer for all the damage they have done.

  10. Guest
    on August 22, 2012 at 3:40 pm

    My husband has been on lyrica for about a year now. At first he had some numbness in his arm/legs and trouble sleeping. Now he has a lot more side effects like: serve back and leg pain, can't remember anything, forget what he's saying while talking, mood changes, depression, etc.

  11. Guest
    on August 20, 2012 at 12:10 pm

    I was put on lyrica in 2006 for serious fibromyalgia pain. I was not warned about any of the side effects. I have suffered and still suffer from a great deal of horrible side effects. I have declined in overall health and functioning. Neurologically and my physical pain has continued to increase. My life and my mind and body(gained 75 lbs) have been so altered. HAD I BEEN PROPERLY WARNED, I NEVER would have started the drug.

  12. Guest
    on August 2, 2012 at 12:08 pm

    After taking Lyrica for about 2 months in early 2008, I showed signs of severe dementia. Even after being off the drug for 4 years, I still suffer lack of focus, concentration, and memory loss. Tests in 2011 showed right side brain damage most likely due to the Lyrica.

    1. Guest
      on August 7, 2012 at 11:27 pm

      My heart breaks for each of you. Since a swimming accident at age 14, I have had many back operations. My Pain Specialist whom I trusted, put me on Lyrica. The nerve pain throughout my body and especially my feet was unbearable. It was electrical shocks, migraines, etc but Lyrica was unbelievably effective with the electric shocks. I talked to my doc and he said keep taking it and the side effects I noticed were awful too: loss of memory, couldn't figure simple tasks out, no way to concentrate, stopped being able to pay our bills...stuttering....can you believe that.! I'd be speaking and instantly I couldn't even remember what I was talking about, it effected my friendships, my income (because I did public speaking), marriage, etc. I wasn't the "good" me. I work hard on word puzzles, using my grandsons educational toys to try to activate my brain. Everyone in my family was worried about me. Just had my 5th back surgery and I am noticing some improvement in my speaking and comprehension ability (which was horrible). My last work presentation, I made errors and realized...I'm a mess..friends and and family said I have some "real strange side effects". I pray daily, done acupuncture, massage therapy, TENS name it to try and get my cognitive ability back. My recent surgeon said my side effects can be permanent and that I should have been taken off that drug immediately. Now I'm terrified what consequences this might have. Disability approved my case and that alone has been very hard to deal with. I'm still adjusting to my new normal but it still scares me, causes anxiety and sad sad days because my entire life has changed. If you cannot trust your doctors well who can you then? I'm doing "brain exercises" and looking for ways to keep my brain strong. But friends out there...I understand. I do not understand how doctors can get away with the poor monitoring I've seen from many surgeons in my 53 years. DON'T RISK TAKING LYRICA. IF YOU CAN, AT ALL AVOID IT.

  13. Guest
    on July 17, 2012 at 6:52 pm

    I have just started taking Lyrica for the second time. I told my doctor about all the swelling and really awful depression it caused the first time I was on it, and he replied "I'd like you to try it again."

  14. Guest
    on July 11, 2012 at 9:23 am

    I am so relieved to see that I am not going mad because of the strange thing that have been happening my body since I started taking Lyrica almost three years ago. My Neurosurgeon prescribed it and I have to say that anything was better than being in as much pain as I was in. I remember glancing at the information leaflet when I started taking it (you think I would know better as I am a Solicitor!) and not being concerned because I did not think that it would happen to me. Events took over from bad to about as bad as it can get - almost lost life, home, job - although the job is still questionable. I decided last night to stop taking my lyrica (x3 times daily 125mg). I am in absolute agony with my back and my surgeon does not want to know about it and it is also a while since my psychiatrist took over the prescription of the lyrica. I really don't know what to do or how to manage all the side affects. My life is falling apart and at this stage ending it successfully is looking like the only option I have. I am scared stiff that the side effects will not go now that I have stopped taking the medication.

  15. Guest
    on June 12, 2012 at 1:19 pm

    I took Lyrica, 300mg for about 9 months and went suddenly deaf in right ear. Withdrawal was the most awful experience of my life. I phoned Pfizer in London, UK and asked if Lyrica could cause deafness, the gentleman went away to look it up, and said it WAS a side-effect, although rare. There are NO warnings of this on the pamphlet, and my doctor had to submit a yellow form form to Pfizer for dire side effects. After several visits to ENT specialist, and a hearing aid, have been told it is permanent, and probably cause by nerve damage. I live in Birmingham, England, so don't know if a firm in US can help or not.

  16. Guest
    on May 23, 2012 at 11:00 am

    Lyrica was prescribed to me, off label, for brachial neuritis. Had all the side effects and severe withdrawal symptoms when I stopped taking. Developed a diverticula in my lower intestine requiring surgery. Had persistent headaches and ear aches. MRI of brain showed small abnormal blood vessel in the the front left part of my brain. Screwed up my career. Went from making mid 100's to 50k or less. Has been two years and still feel like Pfizer stole my life promoting a drug that was not the right treatment for me. Very frustrated when I see Lyrica commercials on TV. Stop letting the drug companies promote to patients who are not qualified for self diagnosis and better education for the medical community on side effects and adverse events.

  17. Guest
    on May 5, 2012 at 8:59 pm

    I too have been taking lyrica for 4 or 5 years now. My teeth are rotting from the inside out too. This is horrible and I've been so depressed about it. I have no money or insurance to even see a dentist. However I think an oral surgeon is what I need, the rot at the gum-line and break off. Help!!

  18. Guest
    on May 1, 2012 at 2:37 pm

    I took Lyrica from 2007 until 2010. Although it did somewhat help my pain from neuropathy...I had terrible side effects. I did weird things...I slept alot. I had hallucinations but continued to take it because there was some pain relief. I noticed that while I was taking Lyrica that my heart rate was very high. In May of 2011, I had triple bypass open heart surgery. My family had to hide things from me while I was taking Lyrica because I would do stupid things. I have never done illicit drugs so I don't know what being high feels like but I would venture to say that I was high on Lyrica. I was also very depressed and at times suicidal. I went off of Lyrica cold turkey...because it is so expensive and Medicare does not cover it. I am really glad that I no longer take it because I no longer hallucinate or sleep constantly. Nor am I suicidal. I truly believe that Lyrica caused the suicidal thoughts since after discontinuing the Lyrica.

  19. Guest
    on March 26, 2012 at 4:26 pm

    I have been on Lyrica for over a year. Presently at 600 mg / day. My fingers twitch all of the time since taking Lyrica.

  20. Guest
    on March 12, 2012 at 9:56 am

    I had been on Lyrica for roughly 3-4 years. During that time, I had noticeable relief from neuropathic pain. However, the side effects are incredibly bad. I had major memory loss (short-term), difficultly concentrating, severe depression, and finally, mood changes (anger, and agitation without relevant cause). Quite frankly, it got so bad that even I knew I wasn't myself - my wife became increasingly concerned. My memory got so bad that I would leave the house to drive a half mile to get milk, and I'd have to call me wife after 2 minutes to ask her where I was going and what I was getting. Never before was I remotely like this!

    I obviously had to stop taking it, as it was becoming impossible to properly function, and the pain relief was not worth the side-effects, pain or no pain! I made some major mistakes on work presentations, and could have easily lost my job! Bad stuff!

    I had anticipated that my memory would return. It has NOT. My concentration has improved, but my short term memory is absolutely terrible. I never had these issues before. I am 50, not 85! I can walk into a room with an important matter, walk 5 feet more and forget. I have to write down and document everything to do my job properly, and record my notes. I no longer trust my memory!

    I should mention that I have now been off Lyrica for about 5 months, so there is no reason for this to still occur, but I know that these are Lyrica side-effects. I am worried terribly about what this drug has done to me.

    1. Guest
      on March 18, 2012 at 2:21 pm

      I also was on Lyrica for about a year until I realized that my school performance was getting worse, I was going for my MBA. I started a different drug and the memory has not come back. It often upsets my wife. The other day my wife told me that our two year old had slept with us for the first few months. I just thought that she slept in her bassinet. My 13 year old often ask me about things that happen when they were little. I can't remember them at all.

    2. Guest
      on May 1, 2012 at 2:45 pm

      I also have short term memory loss. I ended up having all my teeth pulled and getting dentures and my eyesight is horrible. I never had these problems until I started taking Lyrica.

  21. Guest
    on February 7, 2012 at 8:12 pm

    I have been taking Lyrica for 4 years. Before I started taking this medication, I had ALL of my teeth. Since taking Lyrica, my teeth have been rotting from the inside and easily falling out. Now I have 7 teeth. I am not the only one having this problem concerning Lyrica. On other thread posts, I have learned this is happening to hundreds of people taking Lyrica.

  22. Guest
    on January 10, 2012 at 11:28 am

    I believe this drug caused me to lose my job in 2007. I had memory loss, slurred speech and staggering gait. They thought I was drunk. The hospital where I worked even did a blood test on me, which was negative. I was given a choice, resign or be fired. If fired no unemployment comp. I resigned for medical reasons. Prior to that they had me on a 6 month probation. They also said I was a danger to patients. I had worked there 29 years. Lyrica is still affecting my memory. I never noticed any side effects. Others told me.

  23. Guest
    on January 2, 2012 at 11:43 pm

    I have had major side effects after quitting Lyrica, causing me to lose my job. I had seizures, difficulty walking (still do) and cervical dystonia. I never had any of these things before taking or getting off Lyrica. I was on Lyrica for only 8 months (75 mg).

  24. Guest
    on December 22, 2011 at 6:40 am

    I took Pregabalin for 2 months, and have been unable to work since. Even after ceasing the drug my vision is still blurry, I feel "spaced out" a lot of the time and can't concentrate. I could lose my job over this and require months of neuro-cognitive re-training to get my brain functioning again.

  25. Guest
    on December 5, 2011 at 6:39 pm

    This medicine is horrible! Nobody should be taking this stuff, it caused me to gain 50lbs, go nuts and try to kill myself, taking out 3 vehicles in the process. It needs to be taken off the market for patient's safety.

    1. Guest
      on February 2, 2012 at 1:16 pm

      Sorry you had such a bad reaction. Doctor put my hubby on it about 2 years ago for neuropathic pain and it has been a miracle drug for him, with no bad side effects at all. I sure don't want it taken off the market, but would recommend that doctors spend more time observing patients reactions to the drug.

  26. Guest
    on December 3, 2011 at 3:10 pm

    I was on Lyrica for quite some time... Just recently I developed a general numbness on my skin. This numbness is over my entire body.

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